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Infectious Diseases
Tuberculosis
Tuberculosis is a communicable diseases caused by Mycobacterium Tuberculosis. Despite decline in the communicable disease around the world, tuberculosis (TB) is the leading cause of mortality. India tops the list of high TB burden at a rate of 250 per lakh of population. With the advent of biologics (anti TNF-α) treatment for rheumatoid arthritis and IBD, TB incidence rate is likely to increase by 10 fold. Inability to contain TB essentially arises out of difficulty in diagnosing and treatment regimen. To root out TB, it is essential to develop reliable TB diagnosis and different treatment strategy.
Developing new diagnostic methods and improving old methods is the core stone of TB control. The efficacies of various therapeutic regimens were assed. Several questions which remained unanswered for more than 100 years are explored through animal models.
COVID-19
The Novel corona virus emerged in 2019 sent the world in a tail spin, bringing all governments and business to stand still. It truly exposed the lack of knowledge and primitive nature of medical science. Even after the development vaccine, the pandemic is far from over.
Even some of the elementary questions doesn't have any answer. Why the covid infect less children? (heterogeneity of infection). Why covid infection shows heterogeneous response (mild in most of the patients, deadly to some)? Why the much hyped HCQ turned out to be a dud pill? Why antivirals aren't effective against covid? Why having COPD and diabetes comorbidity is deadly for COVID-19? Do we even know the cause of death in covid?
Even the path after infection is not clear. What causes post covid syndrome? Will the vaccine make the covid go away? How the pandemic will eventually pan out for various countries. Haven't we learnt anything in past 100 years regarding infections?
We cogitate over the questions which have enormous implication for science and society.
Pneumonia
Is pneumonia good or bad?
Pneumonia is nothing but migration of immune cells like neutrophils to the site of infection, the lung. The pneumonial response is required for effective handling of pathogen. However, attributed as damaging, drug to suppress the immune response is used to treat pneumonia. Even though such immuno suppression reduce severity of pneumonia, it elevates the risk of death.
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we explore the role of pneumonia in infection outcome. In addition we study and ascertain the severity of infection by various pneumonial pathogens such as Streptococcus Aureus and Pseudomonas
Methilin resistant Streptococcus Aerus
Diarrhea
A strong immune response to pathogens results in diarrheal response.
Escherichia Coli
After the decline of polio, the rotovirus has turned in to dominant diarrheal infection
Rotovirus
Sepsis is a condition where and astronomical immune response detrimental to host, resulting in acute shock and death. They are of multi-pathogenic origin. The sepsis leads to high in hospital mortality rate. understanding the immune response in sepsis can pave way for reduction of in hospital mortality rate
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